Targeting the Endothelium

The endothelium is an active organ with paracrine-endocrine capabilities that directs a multitude of physiological actions both locally and remotely. Cardiac arrest and resuscitation is a model of whole body ischemia reperfusion injury, interventions that have their basis in cytoprotection, reduction of the inflammatory cascade, fibrinolysis and improvement of microvasculature blood flow target the endothelium. This presentation will review pharmacologic, cell targeted therapies and periodic acceleration (pGz) interventions that have the endothelium in part as the target organ. The clinical potential of such interventions as preconditioning, conditioning and postconditioning strategies associated with cardiac arrest will be defined. JOSE A. ADAMS ( ) Mount Sinai Medical Center Div. Neonatology 3-BLUM 4300 Alton Road Miami Beach, Fl 33140, USA Phone: 305-674-2727 Fax: 305-674-2306 E-mail: [email protected] JOSE A. ADAMS SIGNA VITAE 2010; 5 (Suppl 1): 17 23